Garrett was created as a balance to this, "an adrenaline junkie. The show's creators decided "what we wanted to do was really put together a team of misfits in a way, people that you would not necessarily associate with being superheroes on television": hence Eduardo as a slacker, Roland as a "square", and Kylie as moody and sarcastic. Showrunner Bob Higgins told Ability Magazine that the decision to create a new Ghostbusters was taken by the studio, which hoped to reinvigorate a lucrative franchise.
Recurring themes throughout the series are the new team learning to work together despite their differences, Janine's largely unrequited affection for Egon, the love-hate relationship between Kylie and Eduardo that is never resolved, and the Ghostbusters' frequent clashes with authority figures who disbelieve their work. This is reflected by the use of a gritty, rock/ funk-inspired variation of Ray Parker, Jr.'s song " Ghostbusters" as the opening theme written by Jim Latham and performed by voice actor Jim Cummings. The series is styled as a supernatural comedy, following the trend set by its predecessor, but given an updated and darker feel. The series follows the adventures of this "Next Generation" of Ghostbusters tracking down and capturing ghosts all over New York and occasionally beyond the city. Filling the cast are Janine Melnitz, the Ghostbusters' previous secretary who returns to the job, and Slimer, a hungry ghost and general comic relief. These are Kylie Griffin, a goth girl genius and expert on the occult Eduardo Rivera, a cynical Latino slacker Garrett Miller, a young white paraplegic athlete who uses a wheelchair and Roland Jackson, a studious African-American machinery whiz. When ghosts start to reappear, Egon is forced to recruit his lone four students as the new Ghostbusters. Egon Spengler, who still lives in the firehouse to monitor the containment unit, further his studies and teach a class on the paranormal at a local university.
Each member has gone their separate way, except for Dr. Set years after the end of The Real Ghostbusters, lack of supernatural activity has put the Ghostbusters out of business.